What is Methylation-Specific PCR?
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What is Methylation-Specific PCR?
DNA methylation is an important epigenetic process which has diverse roles to regulate gene expression, imprinted genes, inactivation of X chromosomes, and the dysregulation of these patterns in diseases.
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Gene expression, influenced by both DNA and epigenetics, affects emotional regulation and stress responses across generations (Meaney & Szyf, 2005). Trauma-induced epigenetic changes, such as altered DNA methylation, have been observed in descendants of Holocaust survivors (Yehuda et al., 2016) and animals exposed to fear-conditioning (Dias & Ressler, 2014). Variations in 5-HTTLPR (serotonin transport) and COMT (dopamine regulation) genes also contribute to inherited anxiety and mood disorders (
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Gene expression, influenced by both DNA and epigenetics, affects emotional regulation and stress responses across generations (Meaney & Szyf, 2005). Trauma-induced epigenetic changes, such as altered DNA methylation, have been observed in descendants of Holocaust survivors (Yehuda et al., 2016) and animals exposed to fear-conditioning (Dias & Ressler, 2014). Variations in 5-HTTLPR (serotonin transport) and COMT (dopamine regulation) genes also contribute to inherited anxiety and mood disorders (
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