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How Digoxin acts as Cardiotonic in Heart Failure?
Digoxin increases force but decreases rate of contraction of heart. So it is specifically a cardiotonic with opposite action on the rate. It inhibits Na+/K+-ATPase pump thereby increases intracellular calcium levels which are responsible for increase in the force of contraction. The inhibitory effect on cardiac rate by Digoxin is due to its ...
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