BRCA Gene Changes: Cancer Risk and Genetic Testing
A fact sheet about the BRCA1 and BRCA2 genes, what to do if a person tests positive for alterations in one of these genes, and consequences of genetic testing.
BRCA1 and BRCA2 (PDQ®) - NCI - National Cancer Institute
Germline pathogenic variants in BRCA1/BRCA2 are associated with ovarian cancer, fallopian tube cancer, primary peritoneal cancer, male breast cancer, prostate cancer, pancreatic cancer, and early …
Hoja informativa sobre los cambios en el gen BRCA y las pruebas …
Hoja informativa sobre los genes BRCA1 y BRCA2, qué hacer si la prueba de una persona indica que tiene cambios en uno de estos genes y las consecuencias de las pruebas genéticas.
Definition of BRCA1 gene - NCI Dictionary of Cancer Terms
A gene that makes a protein that repairs damaged DNA. Mutations (changes) in the BRCA1 gene significantly increase the risk of developing breast and ovarian cancer.
Genetic Testing Fact Sheet - NCI - National Cancer Institute
As of January 2024, the only FDA-approved DTC genetic test for inherited cancer risk tests for three different BRCA gene variants that are common in people of Ashkenazi Jewish descent.
Discovery – BRCA Connection to Breast and Ovarian Cancer
NCI-funded research helped identify inherited BRCA1 and BRCA2 genetic mutations and their connection to breast and ovarian cancer. From this research, a screening test was also developed to …
Causes and Risk Factors | Breast Cancer - NCI
Dec 2, 2025 · These include certain harmful genetic changes in genes such as BRCA1, BRCA2, PALB2, and PTEN; a strong family history of breast cancer (with multiple relatives diagnosed); and having …
Researchers categorize thousands of BRCA2 mutations as cancerous or ...
Feb 14, 2025 · A team of researchers led by Shyam K. Sharan, Ph.D., Senior Investigator in the Mouse Cancer Genetics Program, has categorized over 6,500 possible single nucleotide variants (SNVs) in …
MRI, Surgery Reduce Cancer Deaths in Women with BRCA Changes
Apr 15, 2024 · For women in whom gene testing finds “harmful changes” in the BRCA1 or BRCA2 genes, leading medical groups recommend that they take specific actions to lower their chances of …
Cancer Risk for Women Carrying BRCA Mutations - NCI
Jul 12, 2017 · The BRCA1 and BRCA2 genes code for proteins that are critical for cells to repair damaged DNA. Specific inherited mutations in these genes increase the risk of several cancer types, …