B-cell lymphoma-2 (BCL-2) family proteins regulate programmed cell death. Some members of the family (such as BCL-2 and BCL-XL) inhibit apoptosis, whereas others (such as BAX and BAK) promote cell ...
The intrinsic pathway to apoptotic cell death converges on events at the mitochondrial outer membrane where interactions between the extended BCL-2 family of proteins determine the fate of the cell.
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