Characterizing clonal evolution in blood cancers like acute myeloid leukemia (AML) is critical for understanding their mutational histories and how cell populations change during disease development.

Serial circulating tumor DNA analysis can demonstrate rapid clonal dynamics that evolve during response and resistance to both standard chemotherapy and targeted therapy of BRAF-mutant colon cancer ...

A review examines the prevailing theory of cancer evolution. The authors highlight both practical and theoretical limitations of the clonal model of cancer evolution and propose areas for improving ...

Clonal cytopenia of undetermined significance (CCUS) corresponds to a clinically more advanced condition defined as CHIP in the presence of one or more persistent and unexplained cytopenia that does ...

The 2026 Sjöberg Prize has been awarded to Charles Swanton of the Francis Crick Institute for his discoveries concerning the clonal evolution of cancer cells and its importance for tumour growth ...

Clonal hematopoiesis (CH), the benign clonal expansion of hematopoietic stem cells, is often caused by somatic sequence variations in genes associated with hematologic malignancies. Over the past ...

Panelists discuss how early relapse in standard-risk patients represents a failure of current risk assessment methods and may require advanced sequencing technologies to identify hidden high-risk ...

Like Plato’s description of the enigma of human existence, stem cells may remain dormant for a person’s life span and never fulfill their potential — that is, “never come to be” — or may differentiate ...

The way in which blood stem cells evolve over a lifespan differs greatly between humans and mice, new research reveals. The findings provide a new understanding of the critical factors that influence ...