A long-standing mystery in bile acid biology has been solved. Bile acids are often introduced as digestion helpers, but they are also powerful chemical messengers that help coordinate metabolism ...

Using cryo-EM structure determination, molecular dynamics simulations, and electrophysiological analyses, researchers from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences ...

MDR3 defects are involved in the development of PFIC3, LPAC, ICP, and DILI. Sterolin 1/2 are cotransporters that transport plant sterols and can lead to sitosterolemia if mutated. MRP2 is responsible ...

A new editorial paper titled "Targeting ABC transporters in PDAC—past, present, or future?" has been published in Oncotarget. Science X Daily and the Weekly Email Newsletter are free features that ...

The two best tennis players in the men’s game will decide who ends the year as world No. 1 at the ATP Tour Finals in Turin, Italy. World No. 2 Jannik Sinner defeated Félix Auger-Aliassime 6-4, 7-6(4) ...

ABSTRACT: Currently, breast cancer is the most common malignant tumour in Chinese women with a high incidence rate, and recurrence and metastasis are the main reasons affecting survival. Breast Cancer ...

From the Institute of Clinical Chemistry, University Hospital of Zurich and Center for Integrative Human Physiology, University of Zurich, Switzerland. High-density lipoproteins and their major ...

From the Department of Pathology/Section on Lipid Sciences (S.C., J.K.S., A.K.G., J.S.P.) and Biochemistry (J.S.P.), Wake Forest School of Medicine, Winston-Salem, NC ...

Abstract Background— Patients with type 2 diabetes mellitus are at increased risk for the development of atherosclerosis. A pivotal event in the development of atherosclerosis is macrophage foam cell ...

Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, Taipei 10507, Taiwan Department of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan Department ...