Stephanie Melchor is a science writer based in Silicon Valley, California. From roundworms to humans, signalling through the Notch protein-receptor family drives embryonic development, cellular ...

Notch is one of the most frequently mutated genes in chronic lymphocytic leukemia (CLL), the most common leukemia in adults in the United States. It is also often mutated in other common B cell tumors ...

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key ...