Previous experience with antiretroviral compounds has indicated that viral replication can be affected through the use of agents that target multiple steps in the HIV lifecycle. Even within the ...

A new study overthrows a long-held theory on how HIV finds its way into host cells. Rather than fusing directly with the host cell membrane, the virus is first engulfed by it to form a vesicle that ...

At the cellular level, HIV-1 transmission involves a highly coordinated process whereby the virus binds to CD4 receptors and one of two coreceptors—CCR5 (R5) or CXCR4 (X4)—on host immune cells, ...

A pharmacy associate professor has developed a novel nanomedicine loaded with genetic material called small interfering RNAs (siRNA) to fight human immunodeficiency virus (HIV) using gene therapy.

HIV hijacks SRRM2 to enlarge nuclear speckles, stabilizing CPSF6 puncta and promoting efficient viral replication.

Interestingly, the anti-HIV-1 targets of triterpene analogs can vary depending on the side chain modification position. C-28 modified betulinic acid analogs are potent HIV entry inhibitors, while C-3 ...