Visualizing how cancer drugs reshape proteins linked to lung cancer

Researchers at Nano Life Science Institute (WPI-NanoLSI) and the Cancer Research Institute at Kanazawa University have ...
Technology Networks

Scientists Uncover New Clues on Lung Cancer Treatment Resistance

Researchers visualized ALK fusion proteins in real time. They showed that ALK inhibitors reshape flexible protein regions to ...
ascopubs.org

EML4-ALK fusion gene in lung adenocarcinoma: A retrospective analysis of the outcome of cisplatin plus pemetrexed treated patients.

Sorafenib treatment efficacy and KRAS biomarker status in the Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) trial. Background: A subset of lung ...
Medscape

EML4-ALK as a Predictive Marker for Response to EGFR Therapy

Investigators at Massachusetts General Hospital in Boston conducted an analysis of the fusion oncogene EML4-ALK and the more well-studied epidermal growth factor receptor (EGFR) mutation among a group ...
Business Wire

Response Genetics Launches EML4-ALK Genetic Test in Lung Cancer

LOS ANGELES--(BUSINESS WIRE)--Response Genetics Inc. (Nasdaq: RGDX), a company focused on the development and sale of molecular diagnostic tests for cancer, today announced that it has expanded its ...
Medical Xpress

Combination therapy can delay resistance of lung cancer cells

A specific genetic alteration, known as an ALK fusion, drives non-small cell lung cancer in some patients. This abnormality leads to excessive activity of the ALK protein, a key cancer promoter. These ...
EurekAlert!

Not all lung cancer patients who could benefit from crizotinib are identified by FDA-approved test

Break apart a couple worm-like chromosomes and they may reconnect with mismatched tips and tails – such is the case of the EML4-ALK fusion gene that creates 2-7 percent of lung cancers. Almost exactly ...
Nature

The Hsp90 inhibitor IPI-504 rapidly lowers EML4–ALK levels and induces tumor regression in ALK-driven NSCLC models

Heat shock protein 90 (Hsp90) is an abundant cellular chaperone protein that maintains the stability, activity and sorting of its protein substrates, which are also called client proteins (Young et al ...
Medical Xpress

"Liquid biopsy" may help earlier detection of lung cancer treatment resistance

A blood test to regularly monitor for the presence of rearrangement of the EML4-ALK gene fusion in patients with non-small cell lung cancer (NSCLC) may help clinicians predict the outcome of treatment ...
Nature

Up-front polytherapy for ALK-positive lung cancer

A new study identifies the RAS-MAPK pathway to be an Achilles' heel of EML4-ALK fusion-positive lung cancer and suggests that up-front combination therapy directed against both pathways can achieve ...

Kanazawa University research: Visualizing how cancer drugs reshape proteins linked to lung cancer

Researchers at Nano Life Science Institute (WPI-NanoLSI) and the Cancer Research Institute at Kanazawa University led have uncovered how targeted lung cancer drugs alter the shape and behavior of a ...